Author/Authors :
Noorbakhsh, Samileh Department of Pediatric - School of Medicine - Research Center of Pediatric Infection Disease - Iran University of Medical Sciences, Tehran , Javahertrash, Naser Department of Pediatric Immunology and Allergy - School of Medicine - Research Center of Pediatric Infection Disease - Iran University of Medical Sciences, Tehran , Tonekaboni, Hassan Department of Pediatric Neurology - School of Medicine - Research Center of Pediatric Infection Disease - Shahid Beheshti University of Medical Sciences, Tehran , Tabatabaei, Azardokht Department of Pediatric - School of Medicine - Research Center of Pediatric Infection Disease - Iran University of Medical Sciences, Tehran , Fatoorechi, Mohammad Ali Department of Pediatric - School of Medicine - Research Center of Pediatric Infection Disease - Iran University of Medical Sciences, Tehran
Abstract :
Mumps infection is endemic in Iran. Our objective was to evaluate the presence of anti mumps
antibodies ( IgM & IgG) in cerebrospinal fluid in mumps meningoencephalitic children. A prospective/crosssectional
study was performed in Tehran, Iran (2003 to 2004) and serum anti mumps antibodies (IgM) were
detected (quantitive; ELISA) in meningoencephaltis patients. Specific anti mumps antibodies (IgM & IgG)
were detected in cerebrospinal fluids of mumps meningoencephalitis cases. 43 meningoencephalitic patients
were tested (59.2% male and 40.8% female). The age of patients was 79.96 ± 4.7 month. 23 (78.7%) cases
had specific mumps IgM in serum. None of cases had IgM antibodies in CSF. Anti mumps IgG antibody was
detected in CSF of 7.5% (2/23) cases. We detected lower than expected frequency of local immunity to
mumps virus in CSF of our cases. For better serologic diagnosis we recommend more sensitive methods like
virus detection (PCR) or short-term culture of lymphocytes from cerebrospinal fluid in future studies.
