Author/Authors :
Foroughipour, Azam Department of Midwifery - Islamic Azad University, Najaf Abad Branch, Isfahan , Norbakhsh, Vajihe Department of Midwifery - Islamic Azad University, Najaf Abad Branch, Isfahan , Hosseinpour Najafabadi, Sara Department of Midwifery - Islamic Azad University, Najaf Abad Branch, Isfahan , Meamar, Rokhsareh Isfahan Neurosciences Research Centre, Isfahan University of Medical Sciences,Isfahan
Abstract :
Sex-related differences in the severity of multiple sclerosis (MS) could be influenced by the sex hormones. Materials and
Methods: This cohort (historical) study evaluated the sex hormone levels during menstrual cycle and their correlation with disease
severity in MS. Result: Patients with MS had significantly lower testosterone, dehydroepiandrosterone sulfate and prolactin levels
than controls in the follicular and luteal phase but lower estradiol levels only in the follicular phase. A positive correlation coefficient
between follicle stimulating hormone and disease severity, and a reverse correlation with estradiol were found. Conclusion: The
hormone-related modulation of disease severity supports the suggestion that sex hormones play a role in MS disease.
Keywords :
Disease severity , estradiol , hormones , multiple sclerosis , progesterone , testosterone , women
