Title of article :
The Effects of L-Asparaginase on Blood Triglycerides, Glucose, and Albumin Levels and Coagulation State in ALL Patients in Pediatric Ward
Author/Authors :
Bani-Hashem, Abdullah Department of Pediatric - School of Medicine - Mashhad University of Medical Sciences , Heydarian, Farhad Department of Pediatric - School of Medicine - Mashhad University of Medical Sciences , Hiradfar, Simin Department of Pathology - Dr. Sheikh Hospital - School of Medicine - Mashhad University of Medical Sciences , Ehteshammanesh, Hojatullah Department of Pediatric - School of Medicine - Mashhad University of Medical Sciences
Abstract :
Asparaginase is one of the most important agents in the treatment of ALL. However, it has some
side effects including dislipidemia, hyperglycemia, coagulopathy and hepatotoxicity. We studied its side effects
on our patients. The effects of L-asparaginase were assessed on 25 new ALL patients (case group) and
25 patients with known ALL who had completed their treatment before. Sixty two percent of cases were male
and remainder was female. The mean age of patients was 7.2 ± 3.8 years. In our patients, there was a rise in
triglycerides (TG) was seen following L- asparaginase administration (P = 0.02). Also, PT prolongation (P =
0.02) and hypoalbominemia (P = 0.002) were detected which could PT prolongation and hypoalbuminemia
may be seen with L-asparaginase therapy that can be prevented with transfusion of FFP. Hypertriglyceridemia
is often asymptomatic with no need for therapy.
Keywords :
L-asparaginase , ALL , hyperlipidemia , hyperglycemia
Journal title :
Astroparticle Physics
