BREAST CANCER RISK ASSESSMENT IN IRANIAN WOMEN BY GAIL MODEL

Background: Due to the high incidence of breast cancer and the effect of its early diagnosis on decreasing morbidity and mortality, we used the Gail model to study breast cancer risk in Iranian women. Methods: This study was done in a simple randomized way. Participants were 2000 Iranian women older than 35 years old. The questionnaire consisted of demographic data such as age, race (optional) marriage status, level of education and standard questions of the Gail model. Gathered data were given in http: //bcra. nci. nih.gov/brc. The breast cancer risk was calculated within the next 5 years and within the 90 years life span. The statistical analysis was done by SPSS software. Results: Mean age of women in the study was 47.95 years. 50% of women had their menarche at/older than fourteen years of age.50% of women had first childbirth in their twenties. 87% had a negative family history of breast cancer.94% had no history of breast biopsy. Of the remaining 6%, no tissue atypia was reported. In the present study, breast cancer risk within 5 years was 0.92% and the breast cancer risk within 90 years of life was 9.14%. 7% showed risk of more than 1.67% in the Gail model. The age ranged between 55-65 years in this high risk group. Conclusion: In our study of breast cancer risk in Iranian women, breast cancer risk was lower than the control group in the Gail model estimate for 5 years and a 90-year life span. (0.92% versus 1.02%, 9.14% versus 11.21%). The differences were statistically significant (p<0.001).