Author/Authors :
Rostamian, A.R Department of Rheumatology - School of Medicine - Medical Sciences/University of Tehran - Tehran, Iran , Naji, A. H. Department of Rheumatology - School of Medicine - Medical Sciences/University of Tehran - Tehran, Iran , Gharibdoost, F. Department of Rheumatology - School of Medicine - Medical Sciences/University of Tehran - Tehran, Iran , Khalvat, A. Department of Rheumatology - School of Medicine - Medical Sciences/University of Tehran - Tehran, Iran , Jafari-Saraf, L Department of Rheumatology - School of Medicine - Medical Sciences/University of Tehran - Tehran, Iran , Saeedfar, K Department of Rheumatology - School of Medicine - Medical Sciences/University of Tehran - Tehran, Iran
Abstract :
Rheumatoid arthritis is the most common inflammatory joint disease with 1 percent
prevalence in community which presents with symmetrical polyarthritis of hands with inflammatory
behavior. Several studies in recent years were conducted for evaluation of inflammatory cytokines such
as IL1-& (Interleukin 1&) and TNF- & (Tumor necrosis factor) in rheumatologic disorders including
rheumatoid arthritis to find new treatment methods base to pathogenesis. In this study different serum
levels of IL1-& and TNF- & in 160 rheumatoid arthritis patients with active and inactive disease and also
disease with or without bone erosion are assessed. 4% of our patients had rheumatoid nodule and 70%
of all patients had positive RF, IL1-&, and TNF- & levels. Active with bone erosion patients had IL1-&
and TNF- & serum levels higher than active without bone erosion patients; it was not significant in Ttest
but it was significant in Mann-Whitney Test. The results was the same as expected; IL1-&, and
TNF- & serum levels were higher in active with bone erosion in comparison with inactive without bone
erosion patients.
