Author/Authors :
Mohanb, Chander Department of Pharmaceutical Sciences, Lovely Professional University, Chaharu, Phagwara, Punjab-144402, India. , Kumara, Pankaj Department of Pharmaceutical Sciences, Lovely Professional University, Chaharu, Phagwara, Punjab-144402, India. , Srinivasan Uma Shankara, Mara Kanam Department of Pharmaceutical Sciences, Lovely Professional University, Chaharu, Phagwara, Punjab-144402, India. , Gulatia, Monica Department of Pharmaceutical Sciences, Lovely Professional University, Chaharu, Phagwara, Punjab-144402, India.
Abstract :
In the present study solid dispersions of the antifungal drug Ketoconazole were prepared with Pluronic F-127 and PVP K-30 with an intention to improve its dissolution properties. Investigations of the properties of the dispersions were performed using release studies, Differential scanning calorimetery (DSC), X-ray powder diffraction (XRD) and Fourier transform infrared (FTIR). The results obtained showed that the rate of dissolution of Ketoconazole was considerably improved when formulated in solid dispersions with PVP K-30 and Pluronic F-127 as compared with pure drug and physical mixtures. The results from DSC and XRD studies showed the transition of crystalline nature of drug to amorphous form, while FTIR studies demonstrated the absence of drug-carriers interaction.
Keywords :
Solid dispersion , Ketoconazole , PVP K-30 , Pluronic F127 , Solvent evaporation , Melt-fusion
