Title of article :
The Relationship Between Vitamin E Plasma and BAL Concentrations, SOD Activity and Ventilatory Support Measures in Critically Ill Patients
Author/Authors :
Ziaie, Shadi Department of Clinical Pharmacy, Faculty of Pharmacy, Tehran University of Medical Sciences, Tehran , Mousavi, Sarah Department of Clinical Pharmacy, Faculty of Pharmacy, Tehran University of Medical Sciences, Tehran , Hashemi, Mohammadreza Department of Clinical Pharmacy, Faculty of Pharmacy, Tehran University of Medical Sciences, Tehran , Mojtahedzadeh, Mojtaba Department of Clinical Pharmacy, Faculty of Pharmacy, Tehran University of Medical Sciences, Tehran , Hamishehkar, Hadi Department of Clinical Pharmacy, Faculty of Pharmacy, Tabriz University of Medical Sciences, Tabriz , Jamaati, Hamidreza Tobacco Prevention and Control Research Center, NRITLD, Masih Daneshvari Hospital, Shahid Beheshti University of Medical Science, Tehran , Hajimahmoodi, Mannan Nursing and Respiratory healt Managment Research Center, NRITLD, Masih Daneshvari Hospital, Shahid Beheshti University of Medical Science, Tehran , Fahimi, Fanak Chronic Respiratory Disease Research Center, NRITLD, Masih Daneshvari Hospital, Shahid Beheshti University of Medical Sciences, Tehran , Farzanegan, Behrooz National Research Institute of Tuberculosis and Lung Disease (NRITLD), Masih Daneshvari Hospital, Shahid Beheshti University of Medical Sciences, Tehran, Iran. cDepartment of Drug and Food Control, Faculty of Pharmacy, Tehran University of Medical Sciences, Tehran , Farzanegan, Behrooz National Research Institute of Tuberculosis and Lung Disease (NRITLD), Masih Daneshvari Hospital, Shahid Beheshti University of Medical Sciences, Tehran, Iran. cDepartment of Drug and Food Control, Faculty of Pharmacy, Tehran University of Medical Sciences, Tehran , Radmand, Golnar National Research Institute of Tuberculosis and Lung Disease (NRITLD), Masih Daneshvari Hospital, Shahid Beheshti University of Medical Sciences, Tehran, Iran. cDepartment of Drug and Food Control, Faculty of Pharmacy, Tehran University of Medical Sciences, Tehran , Vahdani, Behzad National Research Institute of Tuberculosis and Lung Disease (NRITLD), Masih Daneshvari Hospital, Shahid Beheshti University of Medical Sciences, Tehran, Iran. cDepartment of Drug and Food Control, Faculty of Pharmacy, Tehran University of Medical Sciences, Tehran , Nadji, Alireza Virology Research Center, NRITLD, Masih Daneshvari Hospital, Shahid Beheshti University of Medical Sciences, Tehran , Moghaddam, Ghazaleh Department of Drug and Food Control - Faculty of Pharmacy, Tehran University of Medical Sciences, Tehran
Pages :
8
From page :
953
To page :
960
Abstract :
Vitamin E is a potent reactive oxygen metabolites (ROM) scavenger. It is a lipid-soluble vitamin and its main function is to protect polyunsaturated fatty acids against oxidative stress. Twenty-five mechanically ventilated Intensive Care Unit (ICU) adult patients participated in a prospective randomized clinical trial receiving either placebo (10 patients) or 3 IM doses (1000 IU each) of vitamin E (15 patients). We determined plasma and bronchoalveolar lavage (BAL) fluid concentrations of vitamin E and superoxide dismutase (SOD). Among these 25 patients, there were 14 men and 11 women, aged 63.16 ±15.48 years (mean ± SD; range = 33 to 87 years). Vitamin E supplementation resulted in significant differences in plasma and BAL vitamin E concentrations between the two groups (p-value = 0.01, 0.01), decrease in SOD activities (not differ significantly in plasma (p-value = 0.23)), but with significant differences in BAL (p-value = 0.016) and progressive reduction in Acute Physiology and Chronic Health Evaluation II (APACHE II) (p-value = 0.52) and Sequential Organ Failure Assessment (SOFA) (p-value = 0.008) score in vitamin E group. From the results of this study, it seems that supplementation of vitamin E as a potent antioxidant, along with other supportive measures, can be beneficial in decreasing SOD total activity, ROM production and risk of organ failure in critically ill patients.
Keywords :
Vitamin E , SOD , Antioxidant , Oxidative stress , Mechanical ventilation
Journal title :
Astroparticle Physics
Serial Year :
2011
Record number :
2446836
Link To Document :
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