Author/Authors :
Esmaeili, Somayeh Traditional Medicine and Materia Medica Research Centre (TMRC) - Shahid Beheshti University of Medical Sciences, Tehran , Ghiaee, Azadeh Traditional Medicine and Materia Medica Research Centre (TMRC) - Shahid Beheshti University of Medical Sciences, Tehran , Naghibi, Farzaneh Department of Pharmacognosy - School of Pharmacy - Shahid Beheshti University of Medical Sciences, Tehran , Mosaddegh, Mahmoud Department of Pharmacognosy - School of Pharmacy - Shahid Beheshti University of Medical Sciences, Tehran
Abstract :
Malaria is the most serious parasitic disease and one of the oldest recorded diseases in
the world. Because of the resistance of malaria parasites to current drugs, it is necessary to
discover new antiplasmodial drugs. Traditional medicine is one of the important sources of new
antiplasmodial drugs.
In this study, twenty methanolic extracts from different parts of sixteen medicinal plants
used in traditional medicine of Iran for the treatment of “Nobeh fever” and/ or fever were
screened for in-vivo antiplasmodial activity against Plasmodium berghei and cytotoxic effect
on Madin–Darby bovine kidney cells (MDBK).
Eleven species (55%) were found to have antiplasmodial activity. Methanolic extract from
Rosa damascena Mill. reduced parasitemia by 57.7% compared to untreated control mice at
intra-peritoneal (i.p.) injection doses of 10 mg/Kg per day for 4 days. This is the first report that
mentioned in-vivo antiplasmodial activity of Rosa damascena Mill
Keywords :
Rosa damascena , Antiplasmodial , Malaria , Fever , Traditional medicine
