Title of article :
Origanum Majoranum Extract Modulates Gene Expression, Hepatic and Renal Changes in a Rat Model of Type 2 Diabetes
Author/Authors :
Mohamed Soliman, Mohamed Department of Biochemistry - Faculty of Veterinary Medicine - Benha University, Egypt , Nassan, Mohamed Abdo Departments of Pathology and Physiologyd - Faculty of Veterinary Medicine, Zagazig University, Egypt , Ismail, Tamer Ahmed Departments of Pathology and Physiologyd - Faculty of Veterinary Medicine, Zagazig University, Egypt
Abstract :
The present study was conducted to test the effect of Origanum Majoranum Extract (OME)
of leaves on alterations induced in a model of type 2 diabetic rats. Adult male Wistar rats
were fed high fat diet for 3 weeks and injected a single dose of streptozotocin (35 mg/kg)
intraperitoneally to induce type 2 diabetic rats. Diabetic rats were given aqueous extract of
OME in a dose of 20 mg/kg orally for 3 weeks. Changes in lipid profiles, glucose, insulin,
expression of some genes related to glucose metabolism and histopathological changes in liver
and kidney were examined. Administration of OME improved and normalized dyslipidemia
recorded in type 2 diabetic rats together with reduction in glucose and insulin levels. OME
induced up-regulation in gene expression of glucose [adiponectin and glucose transporter-2
(GLUT-2)] and lipid metabolism [lipoprotein lipase (LPL)]. Moreover, OME normalized
histopathological changes occurred in liver and kidney of diabetic rats. OME decreased lipids
accumulation in liver and kidney and increased regeneration of hepatic parenchyma and
restored normal renal architecture with disappearance of fat droplets. In conclusion, OME
improved dyslipidemia associated with type 2 diabetes through regulation of genes related to
glucose and lipid metabolism
Keywords :
Dyslipidemia , Gene expression , Origanum extract , Hepatic and renal histopathology , Type 2 diabetes
Journal title :
Astroparticle Physics
