Author/Authors :
Karimi Zarchi, Ali Akbar Nanobiotechnology Research Center, Baqiyatallah University of Medical Sciences, Tehran , Amini, Mohammad Radiation Biology Research Center, Iran University of Medical Sciences (IUMS), Tehran , Mohammadi, Elham Radiation Biology Research Center, Iran University of Medical Sciences (IUMS), Tehran , Jomeh Farsangi, Zohreh Department of Medical Nanotechnology, School of Advanced Technologies in Medicine (SATiM), Tehran University of Medical Sciences (TUMS), Tehran , Moosavi, Zahra Department of Nursing, School of Nursing and Midwifery, Lorestan University of Medical Sciences, Boroujerd , Ghadiri Harati, Parisa Department of Physiotherapy, University of Social Welfare and Rehabilitation Sciences, Tehran
Abstract :
Physical drug delivery through smart nanocarrier and external stimulus could lead to significant
improvements of drug potency as well as noticeable decrease in unwanted side effects. Currently, many
external energy sources such as light, magnetic fields, ultrasound, ..., are under investigation as external
stimulus for physical drug delivery. The purpose of this paper is to review most recent developments of
triggered release of drugs and biomolecules under external ultrasound exposure. A special attention has also
been paid to the metal nanostructures for ultrasound mediated drug delivery and also, other nanostructures
were also considered. We briefly introduced ultrasound regulation and safety consideration. Further it is
concluded that the use of nanostructures for delivery of active biomolecules in combination with ultrasound
as a stimulus to trigger drug release from the nanocarriers and increased drug penetration has gained much
attention for effective drug delivery and overcoming difficulties of multi-drug resistance of cancer
Keywords :
Drug Nanocarriers , External Trigger Release , High Intensity Focused Ultrasound , Ultrasound , Ultrasound Safety
