Title of article :
Effects of Over-Expression of LOC92912 Gene on Cell Cycle Progression
Author/Authors :
Seghatoleslam, Atefeh Department of Biochemistry - School of Medicine, Shiraz University of Medical Sciences, Shiraz , Zambrano, Alberto Institut de Génétique et de Biologie Moléculaire et Cellulaire (IGBMC), CNRS/INSERM/ULP, Illkirch Cedex, Strasbourg, France
Abstract :
Background: We had previously identified the genes involved
in squamous cell carcinoma of the head and neck using differential
display and DNA microarray techniques. We also reported
the first analytical study on a novel human gene called
LOC92912, which was identified by differential display as a
gene up-regulated in such carcinomas. LOC92912, which is a
putative member of the E2 ubiquitin conjugating enzyme family,
is located on chromosome 15q and encodes a protein of 375
amino acids. In this study, we present the extended analysis of
LOC92912 gene in order to uncover the pathway implicated in
cancer development or progression. We established a series of
RPMI 2650 cell line permanently over-expressing LOC92912
gene, together with their related controls.
Keywords :
LOC92912 , transfection , clonogenicity , cell cycle Introduction
Journal title :
Astroparticle Physics
