Author/Authors :
Nematbakhsh, M Department of Physiology, Isfahan University of Medical Sciences Isfahan , Habibi, H.R Department of Physiology, Isfahan University of Medical Sciences Isfahan , Soltani, N Department of Physiology, Isfahan University of Medical Sciences Isfahan , Hayatdavoodi, P Department of Physiology, Isfahan University of Medical Sciences Isfahan , Naji, H Department of Physiology, Isfahan University of Medical Sciences Isfahan , Borjian, L Department of Physiology, Isfahan University of Medical Sciences Isfahan
Abstract :
The endothelial permeability of aorta (EPA) is influenced by
atherosclerosis. Whether the physiological difference in EPA is a
sex-dependent phenomenon remains to be determined. The
objective of this study was to determine the EPA difference between
male and female rabbits. An experimental model was designed to
obtain 4 groups of animals. The ovariectomized rabbits were fed
with normal (group I) and 1% cholesterol-rich diets (group III). The
male rabbits also received normal (group II) and cholesterol-rich
diets (group IV). After 5 wks, the EPA was measured by Evan Blue
(EB) dye uptake method. The EB uptake was significantly (p<0.05)
lower in females, regardless of the diet they used. In groups I to IV,
the mean±SD EB uptake was 4.83±2.06, 15.15±2.91, 7.01±2.40, and
20.58±3.62 mg/g weight of aorta, respectively. The lower EPA in
females may play a role in reducing the risk of development of
atherosclerosis.
