Author/Authors :
Lankarani, K. B Endocrinology and metabolism Research Center, Nemazee Hospital, Shiraz University of Medical Sciences, Shiraz , Moghadami, M Endocrinology and metabolism Research Center, Nemazee Hospital, Shiraz University of Medical Sciences, Shiraz , Masoumpoor, M. Endocrinology and metabolism Research Center, Nemazee Hospital, Shiraz University of Medical Sciences, Shiraz , Geramizadeh, B Endocrinology and metabolism Research Center, Nemazee Hospital, Shiraz University of Medical Sciences, Shiraz , Yarmohammadi, H Endocrinology and metabolism Research Center, Nemazee Hospital, Shiraz University of Medical Sciences, Shiraz , Omrani, G.R Endocrinology and metabolism Research Center, Nemazee Hospital, Shiraz University of Medical Sciences, Shiraz
Abstract :
Background: Leptin and its receptors have been found in the
human gastric mucosa. Its secretion by gastric mucosa has
generated interest in its probable role in the gastrointestinal
tract and pathophysiology of diseases.
Objective: To determine any possible correlation between
serum leptin level and pathological findings in patients with
duodenal ulcer (DU).
Methods: In a cross-sectional study, 22 patients diagnosed as
DU were randomly selected and compared with 22 healthy
controls. From each participant a fasting blood sample for
measurement of serum leptin level and anti-H pylori antibody
IgG was taken. Two antral biopsies for evaluating the intensity
of gastritis and H. pylori infection were also taken from
patients with DU.
Results: Compared to the control group, serum leptin level
was significantly (p<0.05) higher in patients with DU. Leptin
level also significantly (p<0.05) correlated with the presence
of gastritis and H. pylori infection.
Conclusion: An increase in serum leptin in patients with DU
may be a defense mechanism. There is a possibility that leptin
accelerates ulcer healing
Keywords :
Leptin , Duodenal ulcer , H pylori , gastritis
