Author/Authors :
Movahedian, Ahmad Department of Clinical Biochemistry, Isfahan Pharmaceutical Sciences Research Center, School of Pharmacy and Pharmaceutical Sciences, Isfahan University of Medical Sciences, Isfahan , Sajjadi, S.Ebrahim Department of Pharmacognosy, School of Pharmacy and Pharmaceutical Sciences, Isfahan University of Medical Sciences, Isfahan , Ahmadi ,Mahdi Department of Pharmacognosy, School of Pharmacy and Pharmaceutical Sciences, Isfahan University of Medical Sciences, Isfahan
Abstract :
Increased plasma cholesterol is known to be a major risk related to the development of
coronary artery disease. The main purpose of this study was to determine possible effects
of the ethanolic extract of aerial parts of Peucedanum pastinacifolium on the serum lipids
in hypercholesterolemic rats. Experimental hypercholesterolemia was induced by feeding rats
groups. One group did not receive treatments and served as a control hypercholesterolemic
group. The other four groups were fed the cholesterol-enriched diet in conjunction with
125, 250, 500 mg extract per kg of the body weight along with 20 mg atrovaststin per kg
body weight, in a daily oral dose. A normal group of rats fed with a plain chow diet was also
included in the study. After oral administration for 8 weeks, P. pastinacifolium extract produced
levels and atherogenic indices in hypercholesterolemic groups (P < 0.05). P. pastinacifolium
extract had no effects on serum high-density lipoprotein cholesterol levels in these groups. It is
concluded that the extract of aerial parts of P. pastinacifolium exhibits lipid lowering activity in
hypercholesterolemic rats. However, further investigation would be necessary to evaluate the
mechanism of action of the extract
Keywords :
Peucedanum pastinacifolium , Lipoproteins , Cholesterol , Hypercholesterolemia
