Author/Authors :
Dinarvand, Rasool Department of Pharmaceutics, Faculty of Pharmacy, Tehran University of Medical Sciences, Tehran , Rahmani, Elham Department of Pharmaceutics, Faculty of Pharmacy, Tehran University of Medical Sciences, Tehran , Farbod, Efat Department of Pharmaceutics, Faculty of Pharmacy, Tehran University of Medical Sciences, Tehran
Abstract :
A topical o/w cream containing tretinoin microspheres was prepared. Gelatin microspheres of
tretinoin were prepared using coacervation method. These microspheres contained about 50% w/w
tretinoin. The particle size range of microspheres was between 90-150 μm. In vitro drug release
from microspheres and a cream formulation was studied. It was shown that drug release from
microspheres followed Higuchi kinetics of release. However, drug release from the cream
formulation followed zero order release profile
Keywords :
All-trans-retinoic acid , Tretinoin , Microencapsulation , Gelatin Microspheres , Coacervation , Zero order release , Topical cream
