Title of article
Evaluation the Effect of Amine Type on the Nonisothermally Derived Activation Energy for the Interaction of 3 Antidepressant Drugs with Lactose
Author/Authors
Ghaderi ، Faranak - Urmia University of Medical Sciences , Nemati ، Mahboob - Tabriz University of Medical Sciences , siahi-shadbad ، Mohammad Reza - Tabriz University of Medical Sciences , valizadeh ، Hadi - Tabriz University of Medical Sciences , Monajjemzadeh ، Farnaz - Tabriz University of Medical Sciences
Pages
5
From page
289
To page
293
Abstract
Purpose: Evaluation of drugexcipients compatibility is an important stage during preformulation studies. In the present research, differential scanning calorimetry (DSC) at different heating rates (2.5, 10, 15°C/min) was applied for the kinetic evaluation of fluvoxamine (FLM), sertraline (SER) and doxepin (DOX) binary mixtures with lactose. Methods: Solid state kinetic parameters of the mixtures were calculated using two different thermal methods including ASTM E698 and Starink and the effect of amine type (pKa value) was investigated based on the calculated activation energies. Results: Based on obtained results mean activation energy calculated for FLM, SER and DOX with lactose using ASTM E698 and Starink methods are equal to 335.23, 132.02 and 270.99 kJ/ mol respectively. Conclusion: Results showed that the probability of druglactose interaction is higher in the SERlactose mixture in comparison with other two antidepressant drugs which is consistent with their pKa values.
Keywords
Interaction , DSC , Amine type , Lactose
Journal title
Advanced Pharmaceutical Bulletin
Serial Year
2019
Journal title
Advanced Pharmaceutical Bulletin
Record number
2448510
Link To Document