Author/Authors :
Hosseinsabet, Ali Tehran University of Medical Sciences, Tehran , Faal, Mohsen Tehran University of Medical Sciences, Tehran , Shafiee, Akbar Department of Community Medicine - School of Medicine - Shahid Beheshti University of Medical Sciences, Tehran , Aghajani, Hassan Tehran University of Medical Sciences, Tehran , Sotoudeh Anvari, Maryam Tehran University of Medical Sciences, Tehran , Jalali, Arash Tehran University of Medical Sciences, Tehran , Nozari, Younes Tehran University of Medical Sciences, Tehran , Pourhosseini, Hamidreza Tehran University of Medical Sciences, Tehran , Salarifar, Mojtaba Tehran University of Medical Sciences, Tehran , Amirzadegan, Alireza Tehran University of Medical Sciences, Tehran , Kassaeian, Ebrahim Tehran University of Medical Sciences, Tehran , Alidoosti, Mohammad Tehran University of Medical Sciences, Tehran , Hajizeinali, Alimohammad Tehran University of Medical Sciences, Tehran , Nematipour, Ebrahim Tehran University of Medical Sciences, Tehran
Abstract :
Background: Coronary artery ectasia (CAE) is identified as dilation of one or more segments of coronary arteries that reaches 1.5 times or more, compared with near segments that are normal. Several etiologies like atherosclerosis, autoimmune diseases and congenital anomalies have been proposed for this condition. Vitamin D deficiency activates the renin-angiotensin-aldosterone system, which affects the cardiovascular system. For these reasons, we investigated the serum level of vitamin D in patients with CAE compared with individuals with normal coronary arteries.
Methods: The study group included 30 patients (20 males and 10 females, mean age: 57 ± 9 years) with isolated CAE without any stenotic lesions, and the control group consisted of 60 age/gender matched subjects who had normal coronary angiograms (CAG) (40 males and 20 females, mean age: 57 ± 8 years). All participants underwent CAG at Tehran Heart Center between December 2015 and March 2016. Along with routine lab tests, vitamin D, serum albumin, calcium, phosphorus and alkaline phosphatase levels were analyzed and the unadjusted and adjusted effects of vitamin D on CAE were evaluated using logistic regression model.
Results: The median vitamin D level of the patients with CAE was lower than that of the control group (6.5 [3.0, 18.8] ng/mL vs. 17.7 [8.9, 27.1] ng/mL; P = 0.002). The logistic regression model showed that vitamin D deficiency was a predictor for the presence of CEA (P = 0.013). After adjustment for confounding variables, this association remained significant (P = 0.025).
Conclusion: An association between CAE and vitamin D deficiency was found in our study.
