Title of article
Vitamin E Supplementation Reduces Oxidative Stress in the Male Wistar Rats’ Brain Against Polyvinyl Chloride Products
Author/Authors
Sadeghi, Abbas Department of Anatomy - Medical School - AJA University of Medical Sciences, Tehran , Ghahari, Laya Department of Anatomy - Medical School - AJA University of Medical Sciences, Tehran , Yousefpour, Mitra Department of Physiology - Medical School - AJA University of Medical Sciences, Tehran
Pages
4
From page
1
To page
4
Abstract
Background: Polyvinyl chloride (PVC) exerts toxic effects via the formation of oxidative stress on the brain. Antioxidants such as
Vitamin E (Vit E) can affect free radicals.
Objectives: This study was conducted to decrease damage and oxidative stress against PVC products in rats’ brain by vitamin E.
Methods: In the current study, weused 24 male Wistar rats in four groups (N = 6 rats per group) as the control, Vit E, PVC, PVC plus Vit
E.We orally administered vitamin E and PVC for 40 days. Then the rats were anesthetized and the brain was removed and transferred
to a temperature of -70ºC in order to measure lipid peroxidation.
Results: our results revealed that oral administration of PVC decreased catalase and total antioxidant capacity levels, and increased
malondialdehyde in PVC exposed rats. Vitamin E improved spatial memories by enhancing neurogenesis in the brain.
Conclusions: Exposure to PVC can produce oxidative stress enzymes and make brain damage. Vitamin E, as an antioxidant, can
decrease the toxic effects of PVC and protect the brain.
Keywords
Oxidative Stress , Polyvinyl Chloride , Vitamin E , Brain , Rat
Journal title
Astroparticle Physics
Serial Year
2019
Record number
2448797
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