Title of article :
Green Multicomponent Synthesis of Benzodiazepines in the Presence of CuFe2O4 as an Efficient Magnetically Recyclable Nanocatalyst under Solvent-Free Ball-Milling Conditions at Room Temperature
Author/Authors :
Maleki, A Catalysts and Organic Synthesis Research Laboratory - Department of Chemistry - Iran University of Science and Technology, Tehran , Firouzi-Haji, R Catalysts and Organic Synthesis Research Laboratory - Department of Chemistry - Iran University of Science and Technology, Tehran , Farahani, P Catalysts and Organic Synthesis Research Laboratory - Department of Chemistry - Iran University of Science and Technology, Tehran
Abstract :
In this work, an efficient and green procedure for the synthesis of various substituted 1,5-benzodiazepine derivatives via a one-pot
three-component catalytic reaction is described. The reaction was conducted between o-phenylenediamine, dimedone and aldehyde
derivatives in the presence of CuFe2O4 nanoparticles as a magnetic heterogeneous nanocatalyst under ball-milling conditions at room
temperature. High yields of the products, short reaction times, simplicity of operation, mild reaction conditions, non-toxicity, easy work-up
and purification of the products through crystallization method (chromatography-free) and recyclability of the catalyst are added advantages
of this work.
Keywords :
Multicomponent reactions , Benzodiazepine , Magnetic heterogeneous nanocatalyst , CuFe2O4
Journal title :
Astroparticle Physics
