Title of article :
Multicomponent Solvent-Free Synthesis, Antimicrobial and Antifungal Evaluation of Novel N-Amino Benzylthiolates
Author/Authors :
Beyzaei, H Department of Chemistry - Faculty of Science - University of Zabol , Heidari, H Department of Chemistry - Faculty of Science - University of Zabol , Aryan, R Department of Chemistry - Faculty of Science - University of Zabol
Abstract :
Novel N-amino benzylthiolates were synthesized via multicomponent reaction of malononitrile, isothiocyanates and benzyl halides
under conventional and solvent-free conditions. Various electron-donating and -withdrawing substitutes within both isothiocyanates and
benzyl halides were used to demonstrate the efficiency of new methodology. A broad spectrum of antibacterial and antifungal activities
were observed especially within benzyl halides containing electron-withdrawing aryl substituents.
Keywords :
Multicomponent synthesis , Solvent-free condition , N-Amino benzylthiolate , Antibacterial activity , Antifungal property
Journal title :
Astroparticle Physics
