Synthesis of Symmetrical Triaryl Amines by Nano-CuO Catalyzed Buchwald-Hartwig Cross-coupling Reaction: NH2-Thiadiazole as a New N-source

The one-pot synthesis of symmetrical triaryl amines using aryl halides and 5-methyl-1,3,4-thiadiazole-2-amine as a nitrogen-transfer reagent is reported. Copper nanoparticles improved rate and facility of the synthesis of triaryl amines without require the addition of any ligand. The introduction of a new N-source, using green solvents of PEG/H2O, normal atmospheric conditions and excellent yields under mild reaction conditions are other important features of this work.