Title of article :
The Effect of Essential Oil of Lavandula Angustifolia on Amyloid Beta Polymerization: An In Vitro Study
Author/Authors :
Soheili, Masoud Faculty of Paramedical Sciences - Shahid Beheshti University of Medical Sciences - Tehran, I.R. IRAN , Khalaji, Farzaneh Research Center for Biochemistry and Nutrition in Metabolic Diseases - Kashan University of Medical Sciences - Kashan, I.R. IRAN , Mirhashemi, Mehdi Clinical Biochemistry and Genetics Department - School of Medicine - Qazvin University of Medical Sciences - Qazvin, I.R. IRAN , Salami, Mahmoud Physiology Research Center - Institute for Basic Sciences - Kashan University of Medical Sciences - Kashan, I.R. IRAN
Abstract :
Alzheimer’s Disease (AD) is a progressive neurological disorder associated with
cognitive and memory deficits. Accumulation of amyloid beta (Aβ) plaques is one of the major
causes of AD. Therefore, inhibition of the plaque formation has been aimed to play a preventive
role in the disease. Lavender, through some neuroprotective roles such as antioxidant effects,
is known to be an effective candidate in the treatment of neurodegenerative disorders. In this study using
Thioflavin T Measurement and Atomic Force Microscope (AFM) Imaging, we evaluated the effect of
essential oil of lavender on Aβ polymerization. Thioflavin T Method showed that essential oil enhances the
Aβ aggregation. The results of the AFM method also confirmed it. Our data antagonizes previous
results indicating the clearing effect of aqueous extract of lavender on Aβ plaque. It seems that
the different combination of essential oil and aqueous extract considerably determines if or not
the aggregation occurs
Keywords :
Essential oil , Aggregation Lavender , Amyloid beta , Alzheimer’s disease
Journal title :
Astroparticle Physics
