Title of article
Prevalence of Chlamydia trachomatis in Pregnant Iranian Women: A Systematic Review and Meta-Analysis
Author/Authors
Azami, Milad Student Research Committee - Ilam University of Medical Sciences, Ilam , Badfar, Gholamreza Department of Pediatrics - Behbahan Faculty of Medical Sciences, Behbahan , Mansouri, Akram School of Nursing and Midwifery - Ahvaz Jundishapour University of Medical Sciences, Ahvaz , Yekta Kooshali, Mohammad Hossein Women’s Reproductive Health Research Center - Tabriz University of Medical Sciences , Kooti, Wesam Student Research Committee - Kurdistan University of Medical Sciences, Sanandaj , Tardeh, Zeinab Student Research Committee - Ilam University of Medical Sciences, Ilam , Soleymani, Ali Dezful University of Medical Sciences , Abbasalizadeh, Shamsi Women’s Reproductive Health Research Center - Tabriz University of Medical Sciences
Pages
9
From page
191
To page
199
Abstract
Several studies have been conducted regarding the prevalence of Chlamydia trachomatis, Mycoplasma hominis, and Ureaplasma
urealyticum in pregnant Iranian women. However, it is necessary to combine the previous results to present a
general assessment. We conducted the present study based on systematic review and meta-analysis studies according to
the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA). We searched the national and international
online databases of MagIran, IranMedex, SID, MedLib, IranDoc, Scopus, PubMed, ISI Web of Knowledge,
and Google Scholar search engine for certain MeSH keywords until June 16, 2017. In addition, heterogeneity, sensitivity
analysis, subgroup analysis, and publication bias were performed. The data were analyzed using random-effects model
and Comprehensive Meta-Analysis version 2 and P value was considered lower than 0.05. The prevalence of Chlamydia
trachomatis in 11 surveyed articles that assessed 2864 pregnant Iranian women was 8.74% [95% confidence interval (CI):
5.40-13.84]. The prevalence of Chlamydia trachomatis was estimated 5.73% (95% CI: 2.09-14.73) and 13.55% (95% CI:
11.23-16.25) by enzyme-linked immunosorbent assay (ELISA) and polymerase chain reaction (PCR), respectively which
the difference was not significant (P=0.082). The lowest and highest prevalence of Chlamydia trachomatis was estimated
in Tehran province [4.96% (95% CI: 2.45-9.810)] and Ardabil province [28.60% (95% CI: 20.61-38.20)], respectively. This
difference was statistically significant (P<0.001). Meta-regression for the prevalence of Chlamydia trachomatis based on
year of the studies was significant with increasing slope (P=0.017). According to the systematic review, the prevalence of
Mycoplasma hominis and Urea plasma urealyticum indicated 2 to 22.8% (from 4 articles) and 9.1 to 19.8% (from 3 articles),
respectively. There was no evidence of publication bias (P value for Begg and Eggers’ tests was 0.161 and 0.173, respectively).
The prevalence of Chlamydia trachomatis is high among pregnant Iranian women. Screening pregnant women
as part of preventive measures seem necessary considering the potential for maternal and fetal complications.
Keywords
Ureaplasma Urealyticum , Chlamydia trachomatis , Meta-Analysis , Mycoplasma Hominis , Pregnant Women
Journal title
Astroparticle Physics
Serial Year
2018
Record number
2450404
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