Title of article
An Overview of The Globozoospermia as A Multigenic Identified Syndrome
Author/Authors
Modarres, Parastoo Department of Reproductive Biotechnology - Reproductive Biomedicine Research Center - Royan Institute for Biotechnology - ACECR, Isfahan , Tavalaee, Marziyeh Department of Reproductive Biotechnology - Reproductive Biomedicine Research Center - Royan Institute for Biotechnology - ACECR, Isfahan , Ghaedi, Kamran Department of Biology - Faculty of Sciences - University of Isfahan , Nasr-Esfahani, Mohammad Hossein Department of Reproductive Biotechnology - Reproductive Biomedicine Research Center - Royan Institute for Biotechnology - ACECR, Isfahan
Pages
5
From page
273
To page
277
Abstract
Acrosome plays an integral role during fertilization and its absence in individuals with globozoospermia leads to
failure of in vitro fertilization (IVF) and oocyte activation post-intracytoplasmic sperm injection (ICSI). A variety
of processes, organelles and structures are involved in acrosome biogenesis including, trans-golgi network (TGN),
acroplaxome and cellular trafficking. This review aims to explain roles of related signals and molecules involved in
this process and also describe how their absence in form of mutation, deletion and knockout model may lead to phenomenon
referred to globozoospermia.
Keywords
Acrosome , Globozoospermia , Male Infertility
Journal title
Astroparticle Physics
Serial Year
2019
Record number
2450500
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