Author/Authors :
Modarres, Parastoo Department of Reproductive Biotechnology - Reproductive Biomedicine Research Center - Royan Institute for Biotechnology - ACECR, Isfahan , Tavalaee, Marziyeh Department of Reproductive Biotechnology - Reproductive Biomedicine Research Center - Royan Institute for Biotechnology - ACECR, Isfahan , Ghaedi, Kamran Department of Biology - Faculty of Sciences - University of Isfahan , Nasr-Esfahani, Mohammad Hossein Department of Reproductive Biotechnology - Reproductive Biomedicine Research Center - Royan Institute for Biotechnology - ACECR, Isfahan
Abstract :
Acrosome plays an integral role during fertilization and its absence in individuals with globozoospermia leads to
failure of in vitro fertilization (IVF) and oocyte activation post-intracytoplasmic sperm injection (ICSI). A variety
of processes, organelles and structures are involved in acrosome biogenesis including, trans-golgi network (TGN),
acroplaxome and cellular trafficking. This review aims to explain roles of related signals and molecules involved in
this process and also describe how their absence in form of mutation, deletion and knockout model may lead to phenomenon
referred to globozoospermia.
