Author/Authors :
Mohkam, Masoumeh Pediatric Nephrology Research Center - Research Institute for Children Health - Shahid Beheshti University of Medical Sciences - Tehran, Iran , Afshin, Azadeh Pediatric Nephrology Research Center - Research Institute for Children Health - Shahid Beheshti University of Medical Sciences - Tehran, Iran , Shiari, Reza Pediatric Nephrology Research Center - Research Institute for Children Health - Shahid Beheshti University of Medical Sciences - Tehran, Iran , Nili, Fatemeh Department of Pathology - Imam Khomeini Hospital Complex - Tehran University of Medical Sciences - Tehran, Iran
Abstract :
A 13-year-old boy was admitted in emergency room with sever generalized edema, hypertension and gross hematuria. He just had a positive history of upper respiratory tract infection 2 weeks ago. His laboratory tests revealed glomerular hematuria, nephrotic range proteinuria, low complement levels (both C3 and C4 levels) and normal renal function. Supportive therapy was started for him but after 4 weeks, clinical symptoms were not resolved and complement levels remained in low levels of normal. Kidney biopsy was performed and findings are compatible with c3 glomerulopathy with membranoproliferative histologic pattern (figure 1). His symptoms were resistant to prednisolone and cyclosporine therapy, and two months later he showed pluresia and non-infected skin lesions in both legs
