Author/Authors :
Naseri, S Antimicrobial Resistance Research Center - Mashhad University of Medical Sciences , Darroudi, M Nuclear Medicine Research Center (NMRC) - Ghaem Hospital - School of Medicine - Mashhad University of Medical Sciences , Aryan, E Antimicrobial Resistance Research Center - Mashhad University of Medical Sciences , Gholoobi, A Department of Modern Sciences and Technologies - School of Medicine - Mashhad University of Medical Sciences , Rahimi, H R Department of Modern Sciences and Technologies - School of Medicine - Mashhad University of Medical Sciences , Ketabi, K Antimicrobial Resistance Research Center - Mashhad University of Medical Sciences , Movaqar, A Antimicrobial Resistance Research Center - Mashhad University of Medical Sciences , Abdoli, M Antimicrobial Resistance Research Center - Mashhad University of Medical Sciences , Gouklani, H Molecular Medicine Research Center - Hormozgan University of Medical Sciences, Bandar Abbas , Teimourpour, R Department of Microbiology - School of Medicine - Ardabil University of Medical Sciences, Ardabil , Meshkat, Z Antimicrobial Resistance Research Center - Mashhad University of Medical Sciences
Abstract :
Background and Aims: Hepatitis C virus (HCV) is a member of the Flaviviridae family,
which causes approximately 500,000 deaths annually. HCV infection treatment is often
associated with significant adverse effects. Curcumin is an active ingredient of turmeric
which has therapeutic anti-inflammatory effects in many diseases including infectious ones.
Although curcumin is not soluble in water, if it is synthesized in the form of nanomicelles, it
will be water soluble and can be absorbed in the gastrointestinal tract (GI). In this study, the
antiviral effects of curcumin nanomicelles were investigated on the attachment and entry of
HCV particles.
Materials and Methods: The cytotoxicity of curcumin nanomicelles was determined in
Huh7.5 cells and their antiviral effects on the attachment and entry of HCV was investigated
in a cell culture system.
Results: Curcumin nanomicelles could decrease the viral load in the cell culture supernatants
compared to virus control.
Conclusions: According to the results of this research, we determined the antiviral effects of
curcumin nanomicelles in the later stages of HCV replication.
Keywords :
Hepatitis C virus , Curcumin , Herbal medicines , Nanomicelles
