Author/Authors :
Kiani, MH Department of Poultry and obstetrics - Science and Research Branch - Islamic Azad University, Tehran , Bozaorgmehrifard, MH Department of Poultry and obstetrics - Science and Research Branch - Islamic Azad University, Tehran , Hosseini, H Department of Clinical Science - Faculty of Veterinary Medicine - Karaj Branch - Islamic Azad University, Alborz , Charkhkar, S Department of Poultry and obstetrics - Science and Research Branch - Islamic Azad University, Tehran , Ghalyanchilangerodui, A Department of Microbiology and Immunology - Faculty of Veterinary Medicine - University of Tehran
Abstract :
Newcastle disease (ND) is a highly contagious disease that affects many species of birds and
causes significant economic losses to the poultry industry worldwide and the pathogenicity of
Newcastle disease virus (NDV) strains varies with different virulence. Samples were
collected from chicken commercial farms in Iran during 2014–2015. ND virus was
characterized (NDV) by partial sequences of fusion genome and compared with other NDV
sequences. All viruses showed the amino acid sequence 112 RRQKRF117 at the C-terminus
of the F2 protein and phenylalanine at the N-terminus of the F1 protein, residue 117. These
amino acid sequences were identical to a known virulent motif. Based on the phylogenetic
analysis the Iranian NDV isolates are closely related to the genotype VIId of class II NDV
strains. The result showed that the genotype VIId was dominant and circulating among
chicken farms and caused clinical disease.
