The Prevalence of PantonValentine Lukocidin Gene in Staphylococcus aureus Species Isolated From Nosocomial Infections in Isfahan, Iran

Background: Staphylococcus aureus is a significant pathogen and major cause of nosocomial and communityacquired infections. The current study aimed at investigating the frequency of PantonValentine leukocidin (PVL) gene as a serious virulence factor causing WBC destruction. Methods: Collectively, 100 species of S. aureus were isolated from Isfahan, Iran, hospitals and confirmed by biochemical tests (coagulase, mannitol fermentation, and DNase). The antibiotic resistance patterns were studied by the disk diffusion method. Results: Out of the 100 isolates, 56.2% were PVL positive of which 19.8% from abscess, 51.7% from wound, 23.2% from bedsore, and 5.3% from tracheal secretion. Among the detected isolates, 87.8% were resistant to methicillin. Conclusions: The current study showed the high frequency of PVL in wound strains. Further studies are required to understand the distribution of these virulent isolates in order to decrease the risk of infection. High quality hospital cares as well as new antibiotics is required to combat the multidrug resistant bacteria.