Author/Authors :
Salehi, Iraj Neurophysiology Research Center - Hamadan University of Medical Sciences, Hamadan, Iran , Sahab Soleimani, Maryam Department of Physiology - School of Science - Hamedan Branch, Islamic Azad University, Hamedan, Iran , Pourjafar, Mona Department of Molecular Medicine - School of Science - Hamedan University of Medical Sciences, Hamedan, Iran , Ghasemi Moravej, Fahimeh Department of Anatomy - School of Medicine - Hamadan University of Medical Sciences, Hamadan, Iran , Soleimani Asl, Sara Department of Anatomy - School of Medicine - Hamadan University of Medical Sciences, Hamadan, Iran
Abstract :
Introduction: Lead (Pb) is a neurotoxin that its different effects on the central nervous system
are well-known. Previous studies have reported the potent effects of vitamin C on memory.
The present study was undertaken to evaluate the protective effects of vitamin C against leadinduced
amnesia.
Methods: Male Wistar rats were divided into 4 groups: the control (saline), negative control
(lead), positive control (Vitamin C, 150 mg/kg), and experimental (Lead+Vitamin C). To
induce lead toxicity, the rats received water containing 0.2% Pb instead of regular water for 1
month. Passive avoidance learning was assessed by Shuttle Box 2 months later. Retention was
tested 24 hours after training.
Results: The results showed that lead causes impairment in acquisition and retrieval processes
of passive avoidance learning and memory. However, vitamin C administration reinforced
passive avoidance learning and memory. All results were significant (P<0.001).
Conclusion: Vitamin C administration in rats counteracts the negative effect of lead on spatial
learning and memory.
Keywords :
Lead , Vitamin C , Passive avoidance learning , Rats
