Title of article :
Lupus Erythematosus and Chronic Granulomatous Disease: Report of Four Iranian Patients with ARCGD and One XLCGD
Author/Authors :
Maddah ، Marzieh Asthma and Allergy Research Institute, Tehran University of Medical Sciences , Fazlollahi ، Mohammad Reza Asthma and Allergy Research Institute, Tehran University of Medical Sciences , Shiari ، Reza - Shahid Beheshti University of Medical Sciences , Shahram ، Farhad - Tehran University of Medical Sciences , Mamishi ، Setareh - Tehran University of Medical Sciences , Babaie ، Delara - Shahid Beheshti University of Medical Sciences , Monajemzadeh ، Maryam - Tehran University of Medical Sciences , Sotudeh ، Soheila - Tehran University of Medical Sciences , Hamidieh ، Amir Ali - Tehran University of Medical Sciences , Badalzadeh ، Mohsen Asthma and Allergy Research Institute, Tehran University of Medical Sciences , Tajik ، Shaghayegh Asthma and Allergy Research Institute, Tehran University of Medical Sciences , Sedighipour ، Leila Asthma and Allergy Research Institute, Tehran University of Medical Sciences , Pourpak ، Zahra Athma and Allergy Research Institute, Tehran University of Medical Sciences
Abstract :
Chronic granulomatous disease (CGD) is a rare genetic disorder of neutrophil activity, resulting in increased rate of recurrent infections with catalase #x2013;positive bacteria and fungi, as well as various autoimmune diseases such as sarcoidosis, rheumatoid arthritis, and discoid and/or systemic lupus erythematosus. Few reports have reported lupus erythematosus (LE) in patients with X #x2013;linked CGD (XLCGD) and carriers, and very few in autosomal recessive CGD (ARCGD). Here, we present 5 patients with CGD developing LE at different ages to emphasize on the importance of appropriate follow #x2013;up and treatment in patients with CGD with clinical signs and symptoms of autoimmune diseases and even in those with negative serologic results.
Keywords :
Chronic , Cutaneous , Granulomatous disease , Iran , Lupus erythematosus , Rare diseases
Journal title :
iranian journal of allergy, asthma and immunology
Journal title :
iranian journal of allergy, asthma and immunology
