Author/Authors :
Faghani Aghoozi, Marzieh Department of Midwifery and Reproductive Health - Medical Sciences Faculty - Tarbiat Modares University, Tehran - Department of Midwifery - School of Nursing and Midwifery - Shahroud University of Medical Sciences , Tehranian, Najmeh Department of Midwifery and Reproductive Health - Medical Sciences Faculty - Tarbiat Modares University, Tehran , Ramezani Tehrani, Fahimeh Reproductive Endocrinology Research Center - Research Institute for Endocrine Sciences - Shahid Beheshti University of Medical Sciences, Tehran , Hamta, Amir Pediatrics Clinical Research Development Center - Assistant Professor of biostatistcs - Department of Social Medicine - Faculty of Medical Sciences - Qom University of Medical Sciences , Amreian, Malihe Department of Midwifery - School of Nursing and Midwifery - Shahroud University of Medical Sciences , Kiani, Mahdieh Department of Midwifery - School of Nursing and Midwifery - Shahroud University of Medical Sciences , Joz Mohtashami, Mona Department of Anesthesiology - School of Allied Medicine - Shahroud University of Medical Sciences , Mirzamoradi, Masoumeh Department of obstetrics and Gynecology - Mahdiyeh Hospital - Shahid Beheshti University of Medical Sciences, Tehran
Abstract :
Background: The key role of leptin is regulation of appetite and body
lipid and pregnancy is a condition associated with overeating,
reduction in heating and adaptation of lipid cells, culminating in
increased body fat mass. So, this study was conducted to examine the
relationship between changes in pre-pregnancy BMI and leptin.
Methods: This Longitudinal study was conducted on 45 women in the
first trimester of pregnancy using a longitudinal approach and
convenience sampling method in Tehran city in 2015. The mothers in
terms of pre-pregnancy BMI were divided into two groups: group A
(n=22 with normal BMI) and group B (n=23 with high BMI), with
maternal serum leptin being taken in 6-12 weeks and 15-20 weeks of
pregnancy and measured by enzyme-linked immunosorbent assay
(ELISA). The statistical data were analyzed by SPSS V.21 using
Kolmogorov Smirnov, independent t-test, two-sample Chi square,
Mann-Whitney, Regression, Pearson and Landa tests with P.V<0.05.
Results: The mean age of mothers in the present study was 27.47±5.55
years with a minimum age of 19 and a maximum age of 37 years. The
mean plasma leptin of the first and second trimesters of pregnancy was
significantly higher in the high BMI group than in the normal group.
The correlation showed that the first trimester leptin and changes in
leptin levels of pregnancy with pre-pregnancy BMI were significantly
higher in the normal group (P=0.04 and P=0.003).
Conclusions: BMI before and during pregnancy can be a predictor of
maternal serum leptin in pregnancy weight gain.
