Author/Authors :
Tari, Kaveh Department of Hematology - Faculty of Medical Sciences - Tarbiat Modares University, Tehran , Yarahmadi, Reza Department of Laboratory Sciences - School of Paramedical Sciences - Ahvaz Jundishapur University of Medical sciences, Ahvaz , Tabatabaei, Amir Department of Laboratory Sciences - School of Paramedical Sciences - Ahvaz Jundishapur University of Medical sciences, Ahvaz , ahmadi, Leila Department of Genetics - Faculty of Science - Shahid Chamran University, Ahvaz , Atashi, Amir Department of Hematology - Faculty of Medical Sciences - Tarbiat Modares University, Tehran , shahjahani, Mohammad Department of Hematology - Faculty of Medical Sciences - Tarbiat Modares University, Tehran , Abroun, Saeid Department of Hematology - Faculty of Medical Sciences - Tarbiat Modares University, Tehran , Jalili, Ali Department of Immunology & Hematology - Faculty of Medicine - Kurdistan University of Medical Sciences, Sanandaj
Abstract :
Acute lymphoblastic leukemia(ALL) is due to early stage arrest of lymphoblast development. The translocation of Philadelphia (Ph) chromosome occurs as a result of the BCR-ABL fusion gene, which constitutively produced activated tyrosine kinase. This gene fusion is an important indicator for prognosis in ALL and is associated with poor overall survival and remission duration. BCR-ABL could interfere in establishment of ALL. Therefore, in this study, we will try to investigate most pathological aspects involved in BCR-ABL fusion. Strategies for genetic alterations in B-ALL pathogenesis are discussed. Then, the main cytogenetic changes and genetic subtypes for ALL are highlighted. Moreover, intermediate reactions between cancer stem cells (CSC) related to ALL, its niche and microenvironment is discussed. The main objective in this review is to understand the principle prognosis in ALL to introduce new approaches and treatment alternatives.
