مرکز منطقه ای اطلاع رساني علوم و فناوري - Exercise Preconditioning Improves Behavioral Functions following Transient Cerebral Ischemia Induced by 4-Vessel Occlusion (4-VO) in Rats

Author/Authors :

Tahamtan, Mahshid Rafsanjan University of Medical Sciences, Rafsanjan , Allahtavakoli, Mohammad Rafsanjan University of Medical Sciences, Rafsanjan , Abbasnejad, Mehdi Department of Biology - Faculty of Basic Sciences - Shahid Bahonar University of Kerman, Kerman , Roohbakhsh, Ali Rafsanjan University of Medical Sciences, Rafsanjan , Taghipour, Zahra Department of Anatomy - School of Medical Sciences - Rafsanjan University of Medical Sciences, Rafsanjan , Taghavi, Mohsen Department of Anatomy - School of Medical Sciences - Rafsanjan University of Medical Sciences, Rafsanjan , Khodadadi, Hassan Department of Nursing - Faculty of Nursing - Rafsanjan University of Medical Sciences, Rafsanjan , Shamsizadeh, Ali Rafsanjan University of Medical Sciences, Rafsanjan

Abstract :

Background:􀀃􀀷􀁋􀁈􀁕􀁈􀀃􀁄􀁕􀁈􀀃􀁈􀁙􀁌􀁇􀁈􀁑􀁆􀁈􀀃􀁌􀁑􀁇􀁌􀁆􀁄􀁗􀁌􀁑􀁊􀀃􀁗􀁋􀁄􀁗􀀃􀁈􀁛􀁈􀁕􀁆􀁌􀁖􀁈􀀃􀁇􀁈􀁆􀁕􀁈􀁄􀁖􀁈􀁖􀀃􀁌􀁖􀁆􀁋􀁈􀁐􀁌􀁄􀀒􀁕􀁈􀁓􀁈􀁕􀁉􀁘􀁖􀁌􀁒􀁑􀀃􀁌􀁑􀁍􀁘􀁕􀁜􀀃􀁌􀁑􀀃􀁕􀁄􀁗􀁖􀀑􀀃􀀶􀁌􀁑􀁆􀁈􀀃􀁅􀁈􀁋􀁄􀁙􀁌􀁒􀁕􀁄􀁏􀀃􀁇􀁈􀂿􀁆􀁌􀁗􀁖􀀃􀁄􀁕􀁈􀀃􀁗􀁋􀁈􀀃 main outcome in patients after stroke, our study was designed to investigate whether exercise preconditioning improves the acute behav- 􀁌􀁒􀁕􀁄􀁏􀀃􀁉􀁘􀁑􀁆􀁗􀁌􀁒􀁑􀁖􀀃􀁄􀁑􀁇􀀃􀁄􀁏􀁖􀁒􀀃􀁅􀁕􀁄􀁌􀁑􀀃􀁌􀁑􀃀􀁄􀁐􀁐􀁄􀁗􀁒􀁕􀁜􀀃􀁌􀁑􀁍􀁘􀁕􀁜􀀃􀁉􀁒􀁏􀁏􀁒􀁚􀁌􀁑􀁊􀀃􀁆􀁈􀁕􀁈􀁅􀁕􀁄􀁏􀀃􀁌􀁖􀁆􀁋􀁈􀁐􀁌􀁄􀀑 Methods:􀀃􀀰􀁄􀁏􀁈􀀃􀁕􀁄􀁗􀁖􀀃􀁚􀁈􀁌􀁊􀁋􀁌􀁑􀁊􀀃􀀕􀀘􀀓􀂱􀀖􀀓􀀓􀀃􀁊􀀃􀁚􀁈􀁕􀁈􀀃􀁕􀁄􀁑􀁇􀁒􀁐􀁏􀁜􀀃􀁄􀁏􀁏􀁒􀁆􀁄􀁗􀁈􀁇􀀃􀁌􀁑􀁗􀁒􀀃􀂿􀁙􀁈􀀃􀁈􀁛􀁓􀁈􀁕􀁌􀁐􀁈􀁑􀁗􀁄􀁏􀀃􀁊􀁕􀁒􀁘􀁓􀁖􀀑􀀃􀀨􀁛􀁈􀁕􀁆􀁌􀁖􀁈􀀃􀁚􀁄􀁖􀀃􀁓􀁈􀁕􀁉􀁒􀁕􀁐􀁈􀁇􀀃􀁒􀁑􀀃􀁄􀀃􀁗􀁕􀁈􀁄􀁇􀁐􀁌􀁏􀁏􀀃 30min/day for 3 weeks. Ischemia was induced by 4-vessel occlusion method. Recognition memory was assessed by novel object recognition task (NORT) and step-through passive avoidance task. Sensorimotor function and motor movements were evaluated by adhesive 􀁕􀁈􀁐􀁒􀁙􀁄􀁏􀀃􀁗􀁈􀁖􀁗􀀃􀁄􀁑􀁇􀀃􀁏􀁈􀁇􀁊􀁈􀁇􀀃􀁅􀁈􀁄􀁐􀀐􀁚􀁄􀁏􀁎􀁌􀁑􀁊􀀃􀁗􀁈􀁖􀁗􀀏􀀃􀁕􀁈􀁖􀁓􀁈􀁆􀁗􀁌􀁙􀁈􀁏􀁜􀀑􀀃􀀥􀁕􀁄􀁌􀁑􀀃􀁌􀁑􀃀􀁄􀁐􀁐􀁄􀁗􀁒􀁕􀁜􀀃􀁌􀁑􀁍􀁘􀁕􀁜􀀃􀁚􀁄􀁖􀀃􀁈􀁙􀁄􀁏􀁘􀁄􀁗􀁈􀁇􀀃􀁅􀁜􀀃􀁋􀁌􀁖􀁗􀁒􀁏􀁒􀁊􀁌􀁆􀁄􀁏􀀃􀁄􀁖􀁖􀁈􀁖􀁖􀁐􀁈􀁑􀁗􀀑􀀃􀀃 Results: In NORT, the discrimination ratio was decreased after ischemia (P < 0.05) and exercise preconditioning improved it in ischemic 􀁄􀁑􀁌􀁐􀁄􀁏􀁖􀀑􀀃􀀬􀁑􀀃􀁗􀁋􀁈􀀃􀁓􀁄􀁖􀁖􀁌􀁙􀁈􀀃􀁄􀁙􀁒􀁌􀁇􀁄􀁑􀁆􀁈􀀃􀁗􀁈􀁖􀁗􀀏􀀃􀁄􀀃􀁖􀁌􀁊􀁑􀁌􀂿􀁆􀁄􀁑􀁗􀀃􀁕􀁈􀁇􀁘􀁆􀁗􀁌􀁒􀁑􀀃􀁌􀁑􀀃􀁕􀁈􀁖􀁓􀁒􀁑􀁖􀁈􀀃􀁏􀁄􀁗􀁈􀁑􀁆􀁜􀀃􀁚􀁄􀁖􀀃􀁒􀁅􀁖􀁈􀁕􀁙􀁈􀁇􀀃􀁌􀁑􀀃􀁗􀁋􀁈􀀃􀁌􀁖􀁆􀁋􀁈􀁐􀁌􀁆􀀃􀁊􀁕􀁒􀁘􀁓􀀑􀀃􀀨􀁛􀁈􀁕􀁆􀁌􀁖􀁈􀀃􀁓􀁕􀁈􀁆􀁒􀁑- 􀁇􀁌􀁗􀁌􀁒􀁑􀁌􀁑􀁊􀀃􀁖􀁌􀁊􀁑􀁌􀂿􀁆􀁄􀁑􀁗􀁏􀁜􀀃􀁇􀁈􀁆􀁕􀁈􀁄􀁖􀁈􀁇􀀃􀁗􀁋􀁈􀀃􀁕􀁈􀁖􀁓􀁒􀁑􀁖􀁈􀀃􀁏􀁄􀁗􀁈􀁑􀁆􀁜􀀃􀁌􀁑􀀃􀁗􀁋􀁈􀀃􀁌􀁖􀁆􀁋􀁈􀁐􀁌􀁆􀀃􀁕􀁄􀁗􀁖􀀃􀀋P < 0.001). In the adhesive removal test, latency to touch and remove the sticky labels from forepaw was increased following induction of ischemia (all P < 0.001) and exercise preconditioning decreased these indices compared to the ischemic group (all P < 0.001). In the ledged beam-walking test, the slip ratio was increased following ischemia (P < 0.05). In the ischemia group, marked neuronal injury in hippocampus was observed. These neuropathological changes were attenuated by exercise preconditioning (P < 0.001). Conclusion: Our results showed that exercise preconditioning improves behavioral functions and maintains more viable cells in the dorsal hippocampus of the ischemic brain.