Title of article :
Multivariate Curve Resolution-alternative Least Squares for Simultaneous Kinetic– Spectrophotometric Determination of Furosemide and Rizatriptan in Real Samples Based on their Degradation Study
Author/Authors :
Bahram, Morteza Department of Analytical Chemistry - Faculty of Chemistry - Urmia University, Urmia, Iran , Mohamadzadeh, Negar Department of Analytical Chemistry - Faculty of Chemistry - Urmia University, Urmia, Iran
Abstract :
So far, much research has been devoted to measure drug analytes both in pure form or or in complex matrices, and different
methodologies have been employed with their respective advantages and disadvantages. In this work, we introduce an efficient technique,
with lower cost and shorter time, using MCR-ALS, for simultaneous determination of Furosemide and Rizatriptan benzoate in their
mixtures by analyzing kinetic-spectrophotometric data matrices obtained from monitoring the drug degradation reactions induced by
chlorine at the optimized pH. Because of the presence of high spectral overlapping between the analyzed drugs and similar kinetic profiles,
the obtained matrix is rank-deficient and hence matrix augmentation was performed for simultaneous analysis of drugs in their mixture.
Calibration curves were linear in the ranges 3-50 μM and 2-50 μM for Furosemide and Rizatriptan, respectively. Satisfactory recoveries
were obtained and the method showed a good analytical performance toward determination of Furosemide and Rizatriptan in real samples.
Keywords :
Furosemide , Degradation , Kinetic-spectrophotometric , Rizatriptan , MCR-ALS , Simultaneous
Journal title :
Astroparticle Physics