Title of article
Three-component procedure for the synthesis of new chiral spirooxindolopyrrolizidines via catalytic highly enantioselective 1,3-dipolar cycloaddition
Author/Authors
Taghizadeh ، Mohammad Javad - University of Imam Hossein , Jadidi ، Khosrow - Shahid Beheshti University , Javidan ، Abdollah - University of Imam Hossein
Pages
9
From page
96
To page
104
Abstract
The catalytic highly regio-, diastereo-, and enantioselective synthesis of a small library of spiropyrrolizidineoxindoles via a four-component 1,3-dipolar cycloaddition reaction of azomethine ylides, derived from isatin, with electron-deficient dipolarophile was described. The process occurs at room temperature in aqueous ethanol as a green solvent and in the presence of a bidendatebis(imine)–Cu(II)triflate complex as efficient catalyst.
Keywords
Chiral auxiliaries , chiral spiro , oxindolopyrrolizidines , asymmetric 1,3 , dipolar , azomethineylide , three , component reaction , MCRs , proline , sarcosine.
Journal title
Iranian Chemical Communication
Serial Year
2015
Journal title
Iranian Chemical Communication
Record number
2460970
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