Title of article :
Three-component procedure for the synthesis of new chiral spirooxindolopyrrolizidines via catalytic highly enantioselective 1,3-dipolar cycloaddition
Author/Authors :
Taghizadeh ، Mohammad Javad - University of Imam Hossein , Jadidi ، Khosrow - Shahid Beheshti University , Javidan ، Abdollah - University of Imam Hossein
Abstract :
The catalytic highly regio-, diastereo-, and enantioselective synthesis of a small library of spiropyrrolizidineoxindoles via a four-component 1,3-dipolar cycloaddition reaction of azomethine ylides, derived from isatin, with electron-deficient dipolarophile was described. The process occurs at room temperature in aqueous ethanol as a green solvent and in the presence of a bidendatebis(imine)–Cu(II)triflate complex as efficient catalyst.
Keywords :
Chiral auxiliaries , chiral spiro , oxindolopyrrolizidines , asymmetric 1,3 , dipolar , azomethineylide , three , component reaction , MCRs , proline , sarcosine.
Journal title :
Iranian Chemical Communication
Journal title :
Iranian Chemical Communication
