Title of article
Oxidative aromatization of some 1,4-dihydropyridine derivatives using NaBrO3
Author/Authors
Abdoli-Senejani ، Masoomeh - Islamic Azad university, Arak Branch , Foruzan ، Nilufar - Islamic Azad university, Arak Branch , Bahmani ، Mahnaz - Islamic Azad university, Arak Branch , Momeni Isfahani ، Tahereh - Islamic Azad university, Arak Branch , Dustepour ، Saba - Islamic Azad university, Arak Branch
Pages
9
From page
309
To page
317
Abstract
In this study, oxidation of some 3,5-diacyl or 3,5-diester 1,4-dihydropyridines to corresponding pyridine derivatives using sodium bromate in the presence of NH4Cl, NaHSO4 and Bu4NHSO4 under thermal conditions has been investigated. The yield and structure of formed products is similar under all conditions; however, the reaction is accelerated in the presence of Bu4NHSO4 and NaHSO4. In addition, oxidation of 3,5-diester 1,4-dihydropyridines, against 3,5-diacetyl 1,4-dihydropyridines using sodium bromate in the presence of tetrabutylammonium hydrogen sulfate leads to the corresponding pyridines in shorter reaction times than sodium hydrogen sulfate. The cheapness of reagent, high yielding, easy work up and mild condition make this method a useful addition to the available methods in organic synthesis.
Keywords
1,4 , Dihydropyridine , aromatization , sodium bromate
Journal title
Iranian Chemical Communication
Serial Year
2016
Journal title
Iranian Chemical Communication
Record number
2461016
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