Nanocrystalline SiO2–HClO4: A novel, efficient and green catalyst for the three-component synthesis of pyrimidine derivatives

Nanocrystalline SiO2–HClO4, as a newly reported catalyst, has been used as an efficient and reusable catalyst for the synthesis of pyrimidine derivatives. The procedure can be successfully applied to the efficient synthesis of mono substituted pyrimidine derivatives, using triethylorthoformate, ammonium acetate, methyl ketone derivatives. In practice, this method is a combination of a satisfactory synthesis and more significantly easy product isolation and purification. A simple, high yielding method in the presence of perchloric acid–functionalized silica nanosphere as a catalyst is described.