Isoquinoline promoted synthesis of alkyl 2-(1-alkyl-5-oxo-3- phenyl-2-thioxotetrahydro-4H-imidazol-4-yliden) acetate derivatives

An efficient and one-pot method is described for the synthesis of alkyl 2-(1-alkyl-5- oxo-3-phenyl-2-thioxotetrahydro-4H-imidazol-4-yliden) acetate derivatives via simple reaction of dialkylacetylenedicarboxylate and benzyl phenylthiourea in the presence of isoquinoline, promoted component, under solvent-free conditions. The good yields of the products are synthetic advantage of this environmentally friendly method.