Synthesis, biological and molecular modeling studies of macrocyclic complexes of trivalent metal ions

The macrocyclic complexes of biological importance with 3d transition metals are synthesized by template methodology leading to the formation of the complex [MLX] X2; where L is macrocyclic ligand derived from 3,4-diaminotoluene, 2,4-thiazolidinedione, M=Cr (III) and Fe(III) X is Cl-, CH3COO- or NO3-. Characterization of these complexes are made with the assistance of elemental analyses, molar conductance measurements, magnetic susceptiblities measurements and infrared spectral studies. Molecular modelling was done by Avagadro 1.01 progarm and optimised geometry in which energy calculations of macrocyclic complexes were deterrmined. Synthesized complexes were also screened for their biological activities such as antimicrobial, antifungal and antioxidant activities.