Title of article
One-pot, organocatalytic synthesis of spirooxindoles using citric acid in aqueous media
Author/Authors
Karimi-Jaberi ، Zahed - Islamic Azad University, Firoozabad branch , Fereydoonnezhad ، Abdolhossein - Islamic Azad University, Firoozabad Branch
Pages
10
From page
407
To page
416
Abstract
A facile and efficient multicomponent synthesis of functionalized spirooxindoles has been described through the reaction of isatin, malononitrile or ethyl cyanoacetate, and CH- acids (1,3-dicarbonyl compounds) in the presence of catalytic amount of citric acid in excellent yields with short reaction times in aqueous ethanol. Also, citric acid catalyzed synthesis of 3,3-diindolyl oxindoles by the condensation of isatin with substituted indoles.
Keywords
isatin , malononitrile , indole , spirooxindoles , citric acid
Journal title
Iranian Chemical Communication
Serial Year
2017
Journal title
Iranian Chemical Communication
Record number
2461074
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