HKUST-1 as an efficient and reusable heterogeneous catalyst for synthesis of 1,4-dihydropyridine at room temperature

One-pot synthesis of Hantzsch 1,4-dihydropyridines (1,4-DHP) under solvent-free conditions catalyzed by HKUST-1 metal-organic frameworks are reported here. This method provides 1,4-dihydropyridines (1,4-DHP) in good to excellent yields with minimum amount of catalyst. The present methodology offers several advantages including, ease of the preparation and handling of the catalyst, simple and easy work-up, short reaction time, high yields of the products and recyclability of the catalyst.