Triazolinediones applications and recent advances in click chemistry

Triazolinediones (TADs) are unique reagents in organic synthesis that have also found wide applications in different research disciplines. This work focuses on the recently emerging applications of the triazolinediones chemistry. TAD groups can be reliably clicked onto a range of olefinic reaction partners (Enes and dienes). Recent advances in TAD chemistry includes its roles in bioconjugation of peptides and proteins, derivitization of low-abundant lipid metabolites in biological sample, modular chemical library synthesis, clicking and unclicking protecting groups in organic synthesis, functionalization, and cross-linking of natural plant oils and polymer science.