Ultrasensitive electrochemical online determination of Clarithromycin based on Poly(LAspartic Acid)/Graphite Oxide/Pristine Graphene/Glassy Carbon Electrode

In this work, a novel and extra sensitive method for online continues monitoring of Clarithromycin in whole blood sample was introduced based on coupling of electromembrane extraction (EME) and stripping fast Fourier transform continuous cyclic voltammetry (SFFTCCV). In this method, the potential waveform was continuously applied on a Poly(LAspartic Acid)/Graphite Oxide/Pristine Graphene/Glassy Carbon Electrode and the electrode response was obtained by detracting the background current and in the following integrating the current in the specific potential range of oxidation of the analyte. This method was performed by applying a DC potential and migration of Clarithromycin from the sample solution into a layer of 4methyl2pentanol that is immobilized in the pores of the sheet membrane and then migration into the acceptor solution. A low and valuable detection limit of 1.0 ng ml1 and quantification limit of 6.0 ng ml1 are considered as a part of the sensible results of this experiment. Furthermore, an efficient linearity in the range of 6.01000 ng ml1 were found.