Promising antiinflammatory bioefficacy of saponin loaded silver nanoparticles prepared from the plant Madhuca longifolia

Phytocompounds facilitated synthesis of nanoparticles has created an exceptional impact in the formation of nanoparticles and is used for the synthesis of modern nano drugs. Ignorance about phytochemical composition particularly knowledge of the bioactive principle of medicinal plant restricts the demonstration of the real picture of the enhancement of any bioefficacy. The present communication scientifically established antiinflammatory bioefficacy in seeds of the folk plant Madhuca longifolia and its significant enhancement by bioactive principle (saponin) loaded silver nanoparticles (S@AgNps). A family of four saponins has been explored quantified (3.59%) and characterized (Micro Mass ESITOF MS spectra). Synthesis of S@AgNps has been conducted in a green single step and thoroughly characterized. In vivo assessment of antiinflammatory bioefficacy has been carried out using carrageenan induced hind paw edema in Swiss albino mice model. Antiinflammation bioefficacy of native seed extract (15 mg/kg/bw) was found 46.84% which was further elevated and further rose to 56.10% by saponin at considerable low optimized dose (1.5 mg/kg/bw). Antiinflammatory bioefficacy was further successfully enhanced to (70.99%) by S@AgNps, almost close to that of reference drug (Diclofenac sodium; 76.42%). Saponin loaded silver nanoparticles (S@AgNps) prepared from the seed extract of the plant M. longifolia seem to be an ideal candidate for the development of complimentary herbal nanomedicine for antiinflammation.