Dominant and Recessive Genetic Models of LSP1 Gene rs3817198 Polymorphism and Breast Cancer Risk: A Systematic Review and Meta-analysis Study

Objective: The aim of this meta-analysis was to discover the effect of dominant and recessive genetic models of LSP1 gene rs3817198 polymorphism on breast cancer risk. Material and Method: We performed this meta-analysis according to PRISMA protocol. Three databases, including PubMed/Medline, Web of sciences, and EMBASE were searched. In this meta-analysis, we included all studies that evaluated the association between LSP1 gene rs3817198 and breast cancer risk. ORs and their reported 95% confidence interval (CI) for dominant and recessive inheritance models were extracted from final retrieved studies. ORs were pooled using both fixed and the random-effect models. Egger’s test and contour-enhanced funnel plot were used to evaluate publication bias and small study effect. Twelve publications were eligible for final analysis after observing our defined inclusion and exclusion criteria. Results: Totally, this meta-analysis composed of 15,530 cases and 20,258 controls. This study revealed a significant association between LSP1 gene rs3817198 polymorphism and breast cancer in the dominant genetic model (OR=1.07 [1.01-1.14]). Inversely, no association was found in the recessive genetic model (OR=1.10 [0.93-1.32]). Subgroup analysis displayed a significant association in population-based studies and European American and African population only in the dominant genetic model. Begg’s funnel plot and Egger’s test revealed no publication bias. Conclusion: According to our findings, it seems that LSP1 gene rs3817198 polymorphism is associated with breast cancer risk and this risk is more prominent in Caucasians.