Title of article :
Assessing VEGF mRNA and miR494 expression in peripheral blood collected from patients suffering from oral squamous cell carcinoma
Author/Authors :
Masoum Khani ، Maryam - Islamic Azad University , Mohamadnia ، Abdolreza - National Research Institute of Tuberculosis and Lung Diseases (NRITLD), Shahid Beheshti University of Medical Sciences, Shahid Beheshti University of Medical Sciences , Hosseini ، Farzaneh - Islamic Azad University , Bayat ، Parisa - Tehran University of Medical Sciences , Bahrami ، Naghmeh - Tehran University of Medical Sciences, Tehran University of Medical Sciences
Abstract :
Introduction: Oral squamous cell carcinoma accounts for 2% of all cancers and also is one of #xA0; the top 10 causes of death in humans. The goal of this article is to assess changes of VEGF mRNA and miR494 expression. Materials and Methods: We chose 30 patients with OSCC and 30 healthy people (as a controlled group) and assess the rate of VEGF mRNA and miR494 expression in peripheral blood with realtime PCR technique. Findings: VEGF mRNA marker was positive in 24 out of 30 patients. Also, miR494 was positive in 20 out of 30 patients. Results: Overall based on this article #x2019;s findings, results could count as a diagnostic screening test for OSCC #xA0; detection in early steps of cancer.
Keywords :
Oral squamous cell carcinoma , Early diagnosis , VEGF mRNA , miR494
Journal title :
Journal of Craniomaxillofacial Research
Journal title :
Journal of Craniomaxillofacial Research
