Association Between 50 bp Insertion/Deletion Polymorphism in Promoter of the Superoxide Dismutase1 and Temperament

Introduction: Temperament (mizaj) plays an important role in society’s general health as well as in diagnosis and treatment of diseases. Despite its effectiveness, the mechanisms of temperamentdependent treatment in practical Iranian Traditional Medicine (ITM) has not been well understood yet. This study aimed to evaluate the association between the temperament and superoxide dismutase1 (SOD1) polymorphism. Methods: The study was carried out on healthy blood donors. All participants were from Fars province, southern Iran. To determine the participants’ temperaments, a selfreported identification scale was used. Two hundred eighty males with any of 4 simple temperaments (Warm, Cold, Moist, and Dry) were included. The SOD1 genotypes were determined using a polymerase chain reaction (PCR)based method. Multinomial logistic regression was used to calculate odds ratios (ORs) and 95% CI for the association of temperament with SOD1 polymorphism. Results: No association was found between the insertion/deletion (Ins/Del) polymorphism of SOD1 and each of the temperament groups. Conclusion: The results of this study indicated that the temperament is not affected by the Ins/ Del polymorphism of SOD1. Further research with larger samples and with other genes of antioxidant system is recommended.