Title of article :
Hypoglycemic and hypolipidemic effects of Nelumbo nucifera flower in LongEvans rats
Author/Authors :
Islam ، Dipa Biomedical and Toxicological Research Institute (BTRI), Institute of Food Science and Technology , Huque ، Amdadul Biomedical and Toxicological Research Institute (BTRI), Institute of Food Science and Technology , Sheuly ، Ministry of Education , Mohanta ، Liton Chandra Biomedical and Toxicological Research Institute (BTRI), Institute of Food Science and Technology , Das ، Sadhan Kumar Biomedical and Toxicological Research Institute (BTRI), Institute of Food Science and Technology , Sultana ، Abida - Kishoreganj Polytechnic Institute , Lipy ، Evena Parvin Biomedical and Toxicological Research Institute (BTRI), Institute of Food Science and Technology , Prodhan ، U. K. - Mawlana Bhashani Science and Technology University
Abstract :
Introduction: The study was conducted to assess the hypolipidemic and hypoglycemic effects of Nelumbo nucifera flowers powder in LongEvans rats. Methods: Experimental rats were made hyperlipidemic and diabetic (type 2) by feeding high fat diet (Lab diet, Dalda and Coconut oil = 4: 3: 1) and injecting alloxan respectively. N. nucifera flowers powder in different percentages was mixed with the regular Lab Diet for 21 days feeding. Serum total cholesterol, triglyceride, lowdensity lipoprotein (LDL), highdensity lipoprotein (HDL) and blood glucose levels were evaluated in various groups. Results: Feeding with N. nucifera flowers powder at different percentages to hyperlipidemic groups showed diverse but a significant (P lt; 0.05) decrease in serum total cholesterol, triglyceride and LDLcholesterol levels when compared to control group while HDLcholesterol level was increased significantly (P lt; 0.05). Routine feeding with N. nucifera flowers powder for 21 days resulted in significant decrease in the blood glucose levels of alloxaninduced diabetic rats. Both 20% and 10% of N. nucifera flower powders with Lab Diet significantly (P lt; 0.05) decreased blood glucose level up to 48% and 34%, respectively in comparison to the drug control group treated with glibenclamide which was found with the decreasing capability up to 66% where the higher percentage of N. nucifera flower powder was found to exert more prominent effect in lowering blood glucose level. During comparison to the control group, the above mentioned percentages of N. nucifera flowers powder was found to reduce the blood glucose level around 32.05% and 47.92% respectively. Although not prominent, but the data revealed that the sample was endowed with the body weight declining capability. Conclusion: Results of the experiments affirm that the flower of N. nucifera has potent hypoglycemic and hypolipidemic properties and might be useful in these patients.
Keywords :
Alloxan monohydrate , Diabetes , Hypoglycemia , Hypolipidemia , Medicinal plant
Journal title :
Journal of Herbmed Pharmacology
Journal title :
Journal of Herbmed Pharmacology