In vitro antioxidant, antimicrobial and antiinflammatory activities of five Indian cultivars of mango (Mangifera indica L.) fruit peel extracts

Introduction: All parts of the mango plant contain secondary metabolites that possess several beneficial properties. In the present study, evaluation of in vitro antioxidant, antimicrobial and antiinflammatory activities of five Indian cultivars of mango fruit peel extracts were carried out.Methods: Different solvent (hexane, ethyl acetate, and methanol) extracts of five Indian cultivars of mango fruit peels were prepared by using soxhalate, and the aqueous extract was prepared by maceration. In vitro antioxidant activities of these extracts were determined by using 2,2Diphenyl1picrylhydrazyl (DPPH), 2,2′azinobis 3ethylbenzothiazoline6sulfonic acid (ABTS), hydrogen peroxide (H2O2) and nitric oxide (NO) radical scavenging methods. Their antimicrobial and antiinflammatory activities were determined by agarwell diffusion and HRBC (human red blood cell) methods, respectively.Results: All the five mango peel extracts showed good antioxidant activities, especially the methanolic extract of peel of Sindhura cultivar showed better IC50 values of DPPH (21.62±1.82 μg/mL), ABTS (21.33±1.94 μg/mL), H2O2 (19.87±2.61 μg/mL) and NO (57.29±2.17 μg/mL) radical scavenging activities than other extracts. It also possessed higher contents of phenolics (169.18±3.28 mg of GAE/g) and flavonoids (26.18±1.84 mg of QE/g) than the other extracts. All peel extracts of five cultivars of mango fruit revealed good antimicrobial activities against bacterial and fungal cultures and also possessed significant antiinflammatory activity.Conclusion: The present study revealed that all the mango peel extracts have potential antioxidant activity, as well as better antimicrobial and antiinflammatory activities.