Omega-3 Fatty Acid Modifies Serum HSP 27 in Patients with Cardiovascular Disease: Randomized Double‐Blind Placebo-Controlled Trial

Background: Heat shock proteins 27(HSP-27) is involved in the onset of heart disease by inducing pro-inflammatory immune response against endothelial cells. Omega-3 fatty acids increase anti-inflammatory eicosanoids and contribute to the primary and secondary prevention of cardiovascular disease (CVD). The purpose of the current study is to assess the effect of omega-3 on serum HSP-27 in patient with atherosclerosis. Methods: In the double‐blind placebo-controlled trial study, patients were selected from Tehran Heart Hospital. Both of intervention and placebo groups were 21 males with cardiovascular disease (based on Angiography). The intervention group received omega-3 supplement and placebo group took edible paraffin. Dietary intakes, physical activity level, anthropometric parameters and body composition, were measured. Serum HSP-27 concentration was determined after two months. Results: The difference in serum HSP-27 between two groups was statistically significant (P=0.001) after two months. The difference in change of serum HSP27 between two groups remained significant even after control for serum LDL cholesterol concentration (p=0.002). Conclusion: The study showed that taking omega-3 fatty acids can ameliorate serum HSP-27 as inflammatory parameters. Our results suggest more investigation to assess the pathway omega-3 leads to lower incidence of CVD.